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KMID : 0383819610080010081
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Tuberculosis and Respiratory Diseases
1961 Volume.8 No. 1 p.81 ~ p.84
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Influence of Isoniazid on Visual Acuity
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조장원(趙璋元)/Kyung-Sik Kim
김경식(金敬植)/Chang-Won Cho
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Abstract
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Since the advent of Isoniazid, an excellent antituberculosis remedy, many reports on
the efficary of this drug has been published, while continuous studies an efforts have
been made on the toxic actions and on the improvement of this remedy.
A survey on the effect of Isoniazid to visual acuity was made with 114 healthy male
subjects. For the first step, 94 subjects were selected and divided into 4 groups. They
were medicated as follows; Group Ⅰ 600㎎ a day Group Ⅱ 500㎎ a day Group Ⅲ 400㎎
a day Group Ⅳ 300㎎ a day.
Visual and fundus examinations were done respectively for 47 subjects with visual
disturbances.
For the second step, 20 subjects were instillated with 0.2% INAH solution into the
eyes and were observed the alteration of size and light reactions of the pupils. With the
above considerations, conclusions are made as Follows:
1) The occurrence of refraction anomaly rises with increasing dosage of INAH over
300㎎/day.
2) The refraction anomaly lasted for average 2.7 days after discontinuing the INAH
administration.
3) The refraction anomaly which results from the administration of INAH is most
frequently observed in hyperopic eyes.
4) INAH renders the lens more responsive to the process of accomodation.
5) Opthalmoscopic examinations reveal no abnormal findings.
6) Following instillation of the INAH solution into the eyes, pupils become miotic and
react sluggishly to light.
7) It Is suggessed that above changes resulted from the stimulation of the
parasympathetic nerves.
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